- Tom Holland
Peter Parker/Spider-Man - Jacob Batalon
Ned Leeds - Laura Harrier
Elizabeth „Liz” Toomes - Zendaya Coleman
Michelle „MJ” Jones - Michael Keaton
Adrian Toomes/Vulture - Marisa Tomei
May Parker - Robert Downey Jr.
Tony Stark/Iron Man - Jon Favreau
Harold „Happy” Hogan - Gwyneth Paltrow
Virginia „Pepper” Potts - Tony Revolori
Eugene „Flash” Thompson - Angourie Rice
Elizabeth „Betty” Brant - Tyne Daly
Anne-Marie Hoag - Garcelle Beauvais
Doris Toomes - Donald Glover
Aaron Davis - Logan Marshall-Green
Jackson Brice/Shocker I - Bokeem Woodbine
Herman Schultz/Shocker II - Michael Chernus
Phineas Mason/Tinkerer - Michael Mando
Mac Gargan