- Dan Gilvezan
Peter Parker/Spider-Man, Zoltan Amadeus/Arachnoid
- Frank Welker
Bobby Drake/Iceman, Ojciec Angelicii, Flash Thompson, Francis Byte/Videoman, Matt Murdock, Ms. Lion, Wujek Ben
- Kathy Garver
Angelica Jones/Firestar, Sally, Storm („The X-Men Adventure”)
- June Foray
Aunt May
- William Woodson
J. Jonah Jameson, Namor
- Michael Ansara
Hiawatha Smith
- Michael Bell
Doctor Octopus, Ojciec Ariel i Bartow
- Bob Bergen
Bartow
- Susan Blu
Louise, Monica
- Cathy Cavadini
Ariel
- Bill Callaway
Angel
- Hans Conried
The Chameleon
- Peter Cullen
Red Skull, Mysterio, Bruce Banner/Hulk
- Jerry Dexter
Sunfire
- George Dicenzo
Cyclops („The X-Men Adventure”), Captain America, Lance Macho
- Walker Edmiston
Kingpin, Frankenstein
- Pat Fraley
The Gamesman
- Al Fann
Swarm
- Stanley Jones
Dracula, NightCrawler, Professor X, Dean Wilmer
- Sally Julian
Mona Osborn
- Annie Lockhart
Lightwave, Storm, Honey Dove
- Chris Latta
Beetle, Sandman
- Keye Luke
Genju
- Dennis Marks
Green Goblin, Dr. Faustus
- William Marshall
Tony Stark, The Juggernaut
- Alan Melvin
Electro
- Shepard Menkin
Dr. Doom
- Robert Rigley
Kraven
- Neil Ross
Wolverine, Nathan Price/Cyberiad, Cyclops („A Firestar is Born”)
- Neil Ross
Buzz Mason, Norman Osborn
- Michael Rye
Magneto
- Marilyn Schreffler
Bonnie
- John Stephenson
Mordred, Ymir, Loki, The Shocker
- John Stephenson
Eric the Viking, Colossus, Thunderbird
- Janet Waldo
Shanna the She-Devil, Zerona
- Alan Young
Mr. Frump
- Stan Lee
Narrator (Sezony 2 i 3)
